Butrans (Buprenorphine) Transdermal: Makes use of, Aspect Results, Dosages

Butrans (Buprenorphine) Transdermal: Makes use of, Aspect Results, Dosages

What Is Butrans? Butrans (buprenorphine) pores and skin patches are a prescription opioid ache drugs

What Is Butrans?

Butrans (buprenorphine) pores and skin patches are a prescription opioid ache drugs used to handle extreme around-the-clock ache. It’s not used to deal with acute ache.

Butrans works by binding to varied opioid receptors within the physique to alleviate ache. It really works as a partial agonist on the mu-opioid receptors. It additionally works as an antagonist on the kappa-opioid receptors, an agonist on the delta-opioid receptors, and as a partial agonist on the opioid receptor-like (ORL-1) receptors. Agonists are medication that bind to receptors to supply an analogous response to the receptor and antagonists bind to receptors to dam their response.

As an opioid, Butrans will increase the danger of substance use dysfunction in individuals taking the remedy. Due to this, buprenorphine is taken into account a managed substance.

Butrans is accessible by way of prescription as a transdermal pores and skin patch, which signifies that the drug is slowly absorbed into the physique by way of the pores and skin.

Drug Information

Generic Title: Buprenorphine

Model Title: Butrans

Drug Availability: Prescription

Administration Route: Transdermal

Therapeutic Classification: Opioid

Accessible Generically: Sure

Managed Substance: Schedule III

Lively Ingredient: Buprenorphine

Dosage Kind: Transdermal patch

What Is Butrans Used For?

The FDA authorized transdermal buprenorphine as a long-term therapy for managing extreme, power ache when different ache remedies (e.g., non-opioid analgesics or immediate-release opioids) are ineffective or can’t be tolerated.

Tips on how to Take Butrans

Use this drugs precisely as directed by your healthcare supplier. Don’t use greater than you might be prescribed. When utilizing Butrans, apply the patches to the higher outer arm, higher chest, higher again, or the aspect of the chest each seven days.

The next are basic ideas for utilizing Butrans patches:

  • Keep away from utilizing cleaning soap, alcohol, lotion, oils, or another merchandise to take away leftover adhesive out of your pores and skin. Doing so might trigger extra of the drug to go by way of the pores and skin.
  • Do not take away the patch from its protecting pouch till you might be about to make use of it.
  • Don’t apply multiple patch on the similar time, except your healthcare supplier tells you in any other case. In case you are instructed to make use of two patches, apply them each to the identical web site proper subsequent to one another. Apply and take away them on the similar time.
  • Change your software web site every week. Let three weeks go earlier than reusing the identical web site.
  • Apply to hairless or almost hairless pores and skin websites.

Comply with the directions on the remedy information for when and methods to apply Butrans patches.

Don’t cease taking this remedy with out speaking to your healthcare supplier. Talk about any questions on utilizing this remedy together with your healthcare supplier or pharmacist.


Retailer Butrans patches at room temperature (round 77 levels Fahrenheit). Retailer securely, out of sight and attain of youngsters and pets. Preserve it in a location not accessible by others, together with guests to the house. Place the patch within the Patch-Disposal Unit earlier than disposing of it within the trash. You may additionally get rid of used patches by folding them in half and flushing them down the bathroom.

Off-Label Makes use of

Healthcare suppliers might prescribe buprenorphine for off-label makes use of, that means for circumstances not particularly indicated by the FDA.

Buprenorphine is usually used as a bridge remedy to stop withdrawal signs when changing from high-dose opioids to high-dose sublingual buprenorphine for ache administration.

This isn’t an FDA-approved use, and there’s no proof that buprenorphine successfully treats this situation. Utilizing this remedy with out the recommendation of a healthcare supplier may end up in extreme or life-threatening unwanted side effects.

How Lengthy Does Butrans Take to Work?

Butrans is absorbed by way of the pores and skin and begins working inside hours. Every patch delivers buprenorphine for seven days.

What Are the Aspect Results of Butrans?

This isn’t an entire checklist of unwanted side effects and others might happen. A healthcare supplier can advise you on unwanted side effects. For those who expertise different results, contact your healthcare supplier. It’s possible you’ll report unwanted side effects to the FDA at fda.gov/medwatch or 800-FDA-1088.

Widespread Aspect Results

The most typical unwanted side effects of Butrans are:

Extreme Aspect Results

Name your healthcare supplier instantly if in case you have critical unwanted side effects. Name 911 instantly in case your signs really feel life-threatening or for those who assume you or another person is having a medical emergency. Critical unwanted side effects can embody the next:

  • Adrenal insufficiency (adrenal glands not making sufficient hormones)
  • Androgen deficiency (low intercourse hormones)
  • Biliary spasm (intestine ache brought on by a gallstone being handed)
  • Dependency, abuse, or withdrawal if discontinued
  • Elevated intracranial stress
  • Liver toxicity
  • Paralytic ileus (impaired motion of the bowels)
  • Seizures
  • Extreme allergic response
  • Extreme hypotension (low blood stress)
  • Sleep apnea (sleep problem by which respiratory repeatedly stops and begins)

In extreme circumstances, opioids can result in life-threatening or deadly respiratory melancholy. Be particularly cautious when beginning remedy or in case your dosage is elevated.

Report Aspect Results

Butrans might trigger different unwanted side effects. Name your healthcare supplier if in case you have any uncommon issues whereas taking this remedy.

For those who expertise a critical aspect impact, you or your healthcare supplier might ship a report back to the FDA’s MedWatch Adversarial Occasion Reporting Program or by cellphone (800-332-1088).

Dosage: How A lot Butrans Ought to I Take?

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The dose of this drugs shall be completely different for various sufferers. Comply with your physician’s orders or the instructions on the label. The next info consists of solely the common doses of this drugs. In case your dose is completely different, don’t change it except your physician tells you to take action.

The quantity of medication that you simply take relies on the power of the medication. Additionally, the variety of doses you are taking every day, the time allowed between doses, and the size of time you are taking the medication rely on the medical drawback for which you might be utilizing the medication.

  • For transdermal dosage kind (pores and skin patch):

    • For average to extreme power ache:

      • Adults—In case you are not utilizing different narcotics often, your physician will decide the proper dose. In case you are utilizing different narcotics often, your dose shall be based mostly in your current day by day narcotic dose. Your physician might regulate the dose if wanted. The patch is utilized to the pores and skin and left in place for 7 days.
      • Kids—Use and dose should be decided by your physician.


As a result of attainable dangerous results of this remedy, there could also be modifications to how it’s used.

Being pregnant

Utilizing this remedy throughout being pregnant might trigger life-threatening withdrawal signs within the new child. This situation is known as neonatal opioid withdrawal syndrome.


Breastfeeding just isn’t advisable throughout therapy with Butrans. It could put a breastfed toddler in danger for extreme antagonistic reactions, together with extra sedation and respiratory melancholy.

Use in Kids

Butrans has not been studied in infants and youngsters. Please don’t use it on this inhabitants.

Liver Impairment

Butrans is primarily eradicated by the liver. As Butrans is launched over seven days, different ache remedy is advisable in individuals with extreme liver illness.

Missed Dose

For those who miss a dose of this remedy, take away the patch and apply a brand new one as quickly as you bear in mind. Proceed carrying the patch for as much as seven days. Apply a brand new one if wanted for ache. Don’t use additional patches or double as much as make up for a missed dose. Name your healthcare supplier or pharmacist if not sure what to do.

Overdose: What Occurs If I Take Too A lot Butrans?

For those who imagine you or another person has used extra Butrans than prescribed, take away the Butrans patch(es) instantly and search medical consideration. It’s possible you’ll be handled with opioid antagonists, equivalent to naloxone or doxapram hydrochloride (a respiratory stimulant), and monitored for at the very least 24 hours.

Signs of a Butrans overdose might be extreme and even result in loss of life. Indicators of an overdose embody:

What Occurs If I Take Too A lot Butrans?

For those who assume you or another person might have overdosed on Butrans, name a healthcare supplier or the Poison Management Middle (800-222-1222).

If somebody collapses or is not respiratory after taking Butrans, name 911 instantly.


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It is rather vital that your physician verify your progress if you are utilizing this drugs. This may permit your physician to see if the medication is working correctly and to resolve for those who ought to proceed to take it. Blood assessments could also be wanted to verify for negative effects.

This drugs could also be habit-forming. For those who really feel that the medication just isn’t working as effectively, don’t use greater than your prescribed dose. Name your physician for directions.

Utilizing narcotics for a very long time could cause extreme constipation. To stop this, your physician might direct you to take laxatives, drink lots of fluids, or improve the quantity of fiber in your food plan. Make sure to comply with the instructions fastidiously, as a result of persevering with constipation can result in extra critical issues.

Utilizing this drugs if you are pregnant might trigger neonatal withdrawal syndrome in your new child child. Inform your physician straight away in case your child has an irregular sleep sample, diarrhea, a high-pitched cry, irritability, shakiness or tremors, weight reduction, vomiting, or fails to realize weight.

This drugs will add to the results of alcohol and different central nervous system (CNS) depressants. CNS depressants are medicines that decelerate the nervous system, which can trigger drowsiness or make you much less alert. Some examples of CNS depressants are antihistamines or drugs for allergy symptoms or colds, sedatives, tranquilizers, or sleeping drugs, different prescription ache drugs or narcotics, benzodiazepines, drugs for seizures or barbiturates, muscle relaxants, or anesthetics, together with some dental anesthetics. This impact might final for a number of days after you cease utilizing this drugs. Test together with your physician earlier than taking any of the opposite medicines listed above if you are utilizing this drugs.

Test together with your physician straight away if in case you have darkening of the pores and skin, diarrhea, dizziness, fainting, lack of urge for food, psychological melancholy, nausea, pores and skin rash, uncommon tiredness or weak spot, or vomiting. These could also be signs of adrenal gland issues.

Test together with your physician straight away if in case you have darkish urine, basic tiredness and weak spot, light-colored stools, nausea and vomiting, higher proper abdomen ache, and yellow eyes and pores and skin. These could also be signs of liver issues.

This drugs might make you dizzy, drowsy, confused, or disoriented. Be sure you understand how you react to this drugs earlier than you drive, use machines, or do the rest that might be harmful if you’re dizzy or not alert.

Dizziness, lightheadedness, or fainting might happen while you stand up all of a sudden from a mendacity or sitting place. Getting up slowly might assist reduce this drawback. Additionally, mendacity down for some time might relieve the dizziness or lightheadedness.

For those who develop swelling, burn, or blisters on the software web site, cease utilizing this drugs and inform your physician straight away.

This drugs might trigger critical allergic reactions, together with anaphylaxis. Anaphylaxis will be life-threatening and requires quick medical consideration. Name your physician straight away if in case you have a rash, itching, hoarseness, hassle respiratory, hassle swallowing, or any swelling of your fingers, face, or mouth if you are utilizing this drugs.

Warmth could cause the buprenorphine within the patch to be absorbed into your physique quicker. This may occasionally improve the prospect of significant unwanted side effects or an overdose. While you’re utilizing this drugs, don’t use a heating pad, a sunlamp, or a heated water mattress, and don’t sunbathe, or take lengthy baths or showers in scorching water. Additionally, verify together with your physician for those who get a fever.

You probably have been utilizing this drugs often for a number of days, don’t all of a sudden cease utilizing it with out first checking together with your physician. It’s possible you’ll be directed to progressively cut back the quantity you might be utilizing earlier than stopping therapy fully to minimize the prospect of withdrawal unwanted side effects (eg, abdomen cramps, fever, runny nostril, anxiousness, or restlessness).

If the patch comes off and unintentionally sticks to the pores and skin of one other individual, they need to take the patch off instantly and wash the uncovered space with water. The uncovered individual ought to then search medical consideration.

Utilizing an excessive amount of buprenorphine, or taking an excessive amount of of one other narcotic whereas utilizing buprenorphine, might trigger an overdose. If this happens, get emergency assist straight away. Signs of an overdose embody: drowsiness, excessive dizziness or weak spot, irregular, quick or gradual, or shallow respiratory, pale or blue lips, fingernails, or pores and skin, pinpoint pupils, relaxed and calm, gradual heartbeat or respiratory, seizures, sleepiness, hassle respiratory, or chilly, clammy pores and skin. Inform your physician straight away for those who discover these signs. Your physician might also give naloxone to deal with an overdose.

This drugs might trigger sleep-related respiratory issues (eg, sleep apnea, sleep-related hypoxemia). Your physician might lower your dose if in case you have sleep apnea (cease respiratory for brief intervals throughout sleep) whereas utilizing this drugs.

Utilizing an excessive amount of of this drugs might trigger decreased infertility (unable to have youngsters). Speak together with your physician earlier than utilizing this drugs for those who plan to have youngsters.

Test together with your physician straight away if in case you have anxiousness, restlessness, a quick heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear issues that aren’t there. These could also be signs of a critical situation known as serotonin syndrome. Your threat could also be increased for those who additionally take sure different medicines that have an effect on serotonin ranges in your physique.

Don’t take different medicines except they’ve been mentioned together with your physician. This consists of prescription or nonprescription (over-the-counter [OTC]) medicines and natural or vitamin dietary supplements.

What Are the Causes I Shouldn’t Take Butrans?

Keep away from taking Butrans if you’re allergic to buprenorphine or another elements of this remedy.

Don’t use Butrans if in case you have:

  • Vital respiratory melancholy
  • Acute or extreme bronchial bronchial asthma 
  • An obstruction in your abdomen or intestines, together with paralytic ileus

What Different Medicines Work together With Butrans?

Be careful for these drugs when taking Butrans, as they will have an effect on the way it works within the physique.


Keep away from combining Butrans with benzodiazepines as the mixture might improve the danger of respiratory melancholy. Examples embody:

CYP3A4 Inhibitors and Inducers

Beginning CYP3A4 inhibitors or discontinuing CYP3A4 inducers might improve Butrans concentrations. 

Examples of CYP3A4 inhibitors embody, however usually are not restricted to:

CYP3A4 inducers can embody, however usually are not restricted to:

Serotonergic Medicine

Coadministration with these brokers might improve the danger of serotonin syndrome, as serotonergic medication stimulate the serotonin receptors.

Examples of serotonergic medication embody triptans (e.g., sumatriptan), antidepressants like serotonin norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs).

Blended Agonist/Antagonist Analgesics

Keep away from utilizing combined agonist/antagonist analgesics, equivalent to naltrexone, with Butrans as a result of they might have an effect on the way it works or set off withdrawal signs.

This isn’t a complete checklist of medicines that will have an effect on how Butrans works. Share a listing of your present drugs and dietary supplements together with your healthcare supplier or a pharmacist. Some medicines can improve the danger of extreme unwanted side effects from buprenorphine. 

What Medicines Are Comparable?

Medicines just like Butrans embody:

  • Lidoderm (lidocaine topical patch)
  • Fentanyl transdermal patch
  • Aspercreme Lidocaine Patch (lidocaine topical patch)

Lidoderm (Lidocaine Topical Patch)

Like Butrans, Lidoderm is authorized for adults solely. It really works by inhibiting nerve impulses to cut back sensitivity to ache (numbing remedy). In contrast to Butrans, this patch could also be lower to measurement and utilized over painful areas. It’s not dosed across the clock. As a substitute, it’s utilized day by day to probably the most painful areas for 12 hours, then eliminated for an additional 12 hours. It could be used throughout being pregnant and breastfeeding as minimal systemic absorption is anticipated.

Fentanyl Transdermal Patch

Fentanyl is an opioid ache remedy used to deal with average to extreme power ache across the clock. It’s not for treating gentle or occasional ache or surgery-related ache. It really works by binding numerous opioid receptors within the physique to offer ache aid.

Attributable to its potential for abuse, fentanyl can be a managed remedy like Butrans. It is usually dosed across the clock, eradicating and changing the patch each three days. It’s authorized in adults and youngsters 2 years and older, with dose changes required for kidney and liver illness. Like Butrans, keep away from warmth publicity as warmth causes speedy remedy absorption, leading to poisonous ranges.

Aspercreme Lidocaine Patch (Lidocaine Topical Patch)

Aspercreme Lidocaine patch is a ache aid patch accessible over-the-counter (OTC) with no prescription. It really works by inhibiting nerve impulses to cut back sensitivity to ache. It’s utilized each six to eight hours. It’s authorized to be used in youngsters over 12 years previous.

Steadily Requested Questions

  • Can Butrans be uncovered to warmth?

    Keep away from direct warmth publicity when utilizing Butrans. Warmth might trigger extra of the remedy to be absorbed from the pores and skin for all patches. With a drug like Butrans, this elevated absorption can shortly change into life-threatening. Warmth sources to keep away from embody heating pads or electrical blankets, warmth or tanning lamps, saunas, scorching tubs, and heated waterbeds.

  • What can I do if Butrans is irritating my pores and skin?

    Be sure you rotate the applying web site of Butrans every time you reapply. Don’t shave your pores and skin proper earlier than making use of Butrans, as this may occasionally irritate the pores and skin even additional. As a substitute, clip the hair on the software web site if wanted

  • Can Butrans be coated with tape if it doesn’t stick?

    Butrans could also be coated solely with Bioclusive or Tegaderm movie dressings. Place Butrans on dry, non-lubricated pores and skin to assist it stick. Press down together with your palm over the patch. Apply to a hairless or almost hairless pores and skin web site. Keep away from touching the sticky aspect of the patch whereas making use of it. If Butrans falls off in the course of the seven-day dosing interval, dispose correctly and place a brand new patch at a unique pores and skin web site.

  • How do I get rid of used patches?

    To dispose in family trash utilizing the Patch-Disposal Unit:

    1. Peel again the disposal unit liner
    2. Place the sticky aspect of the patch on the indicated space on the disposal unit 
    3. Shut by folding the sticky sides collectively. Press firmly over your entire disposal unit to seal.

    To dispose in the bathroom:

    1. Take away the patch
    2. Fold the sticky sides collectively and instantly flush down the bathroom.

    Unused patches should be faraway from their protecting pouch and the protecting liner eliminated earlier than flushing. Throw the pouch and the protecting liner within the trash.

How Can I Keep Wholesome Whereas Taking Butrans?

Butrans is significant in treating around-the-clock ache that doesn’t reply to different ache remedies like non-opioid analgesics or immediate-release opioids. Comply with all instructions in your prescription label and browse all remedy guides earlier than utilizing this remedy. 

Individuals utilizing Butrans are in danger for critical unwanted side effects. Don’t use this drugs to deal with any situation your healthcare supplier just isn’t conscious of and has not prescribed it for. Misusing this drugs can result in habit, overdose, or loss of life. Buprenorphine is a drug of potential abuse. Subsequently, it is very important inform your healthcare supplier for those who really feel an urge to make use of extra of this drugs. By no means use buprenorphine in bigger quantities or for longer than prescribed. Retailer in a spot the place others can’t entry it. Promoting or gifting away buprenorphine is in opposition to the regulation.

Bear in mind to maintain each used and unused patches out of the attain of youngsters or pets. The quantity of buprenorphine in a used pores and skin patch might be deadly to a toddler or pet. Don’t cease Butrans all of a sudden, or you would have withdrawal signs. Seek the advice of together with your healthcare supplier on methods to cease utilizing Butrans safely.

You probably have hassle remembering to make use of this remedy, contemplate setting alarms in your cellphone or calendar. As with all drugs, focus on any questions or considerations about your therapy with a healthcare supplier or pharmacist.

Medical Disclaimer

Verywell Well being’s drug info is supposed for instructional functions solely and isn’t supposed to switch medical recommendation, analysis, or therapy from a healthcare supplier. Seek the advice of your healthcare supplier earlier than taking any new remedy(s). IBM Watson Micromedex supplies a number of the drug content material, as indicated on the web page.

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